Last edited by Mazujind
Monday, July 27, 2020 | History

2 edition of Oseltamivir for the treatment of suspected influenza found in the catalog.

Oseltamivir for the treatment of suspected influenza

Donald Robert Husereau

Oseltamivir for the treatment of suspected influenza

a clinical and economic assessment

by Donald Robert Husereau

  • 181 Want to read
  • 12 Currently reading

Published by Canadian Coordinating Office for Health Technology Assessment in Ottawa, Ont .
Written in English

    Subjects:
  • Antiviral Agents -- therapeutic use.,
  • Antiviral agents -- Therapeutic use -- Cost effectiveness.,
  • Antiviral agents -- Therapeutic use.,
  • Influenza -- Chemotherapy.,
  • Influenza -- drug therapy.,
  • Influenza -- prevention & control.

  • Edition Notes

    StatementDonald R. Husereau, Bruce Brady, Allison McGeer.
    SeriesTechnology report -- issue 21, Technology report (Canadian Coordinating Office for Health Technology Assessment) -- issue 21.
    ContributionsBrady, Bruce., McGeer, Allison., Canadian Coordinating Office for Health Technology Assessment.
    Classifications
    LC ClassificationsRM411 .H87 2001
    The Physical Object
    Paginationviii, 90 p. :
    Number of Pages90
    ID Numbers
    Open LibraryOL19296572M
    ISBN 101894620267, 1894620259

      The respective reported mean values of inhibitory concentrations of 50% of zanamivir and oseltamivir were and nmol/L for influenza A/H1N1, and nmol/L for influenza A/H3N2, and and nmol/L for influenza B [].These findings may explain our results from a clinical context, because they reveal that oseltamivir is slightly more effective against influenza . Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR ;57[No. RR-7]).This report contains information on treatment and chemoprophylaxis of influenza virus infection and provides a summary of the effectiveness and safety of antiviral treatment medications.

      Oseltamivir is the recommended drug both for prophylaxis and treatment (see Table 1 for dosing). In the current phase, if a person conforms to the case definition of suspect case, he or she would be provided oseltamivir, 43 Oseltamivir is generally well tolerated. Gastrointestinal side effects (nausea, vomiting) may increase with increasing doses, particularly those above mg per day. Treatment of influenza is 10 mg twice daily for 5 days. Post exposure prophylaxis of influenza is 10 mg once daily for 10 days (up to 28 days during an epidemic). Treatment of suspected or confirmed oseltamivir resistant influenza is 10 mg twice a day for up to 10 days (off-label duration).

    Influenza A (H5N1) virus causes severe disease in humans and poses an unprecedented pandemic threat. The neuraminidase inhibitor oseltamivir constitutes an important treatment option, and. Oseltamivir significantly reduced the time to alleviation of symptoms in non-asthmatic children and decreased the incidence of self-reported pneumonia. Relenza (zanamivir) significantly reduced the risk of bronchitis in adults with influenza. Neither treatment was a significant improvement over placebo in time to symptom alleviation in.


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Oseltamivir for the treatment of suspected influenza by Donald Robert Husereau Download PDF EPUB FB2

Oseltamivir is used for the prevention and treatment of influenza caused by influenza A and B viruses. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.

The WHO supports its use for severe illness due to confirmed or suspected influenza virus infection in critically ill people who have been lism: Hepatic, to oseltamivir carboxylate. The cost-effective treatment of suspected influenza using oseltamivir in a primary care setting depends largely on two factors: (1) the accuracy of diagnosis of influenza by the primary care practitioner; and (2) the likelihood of patients being treated within a 48 hour period from the onset of symptoms.

For hospitalized patients with suspected or confirmed influenza, initiation of antiviral treatment with oral or enterically-administered oseltamivir is recommended as soon as possible. Antiviral treatment might be effective in reducing morbidity and mortality in hospitalized influenza patients, especially adults, even if treatment is started.

Deng WW(1), Li QY, Zhong NS; "Oseltamivir in the treatment of suspected influenza patients" Study Group. Author information: (1)Department of Respiratory Disease, Shanghai Ruijin Hospital, ShanghaiChina.

OBJECTIVE: To evaluate the efficacy and safety of oseltamivir in the treatment of suspected influenza by: Oseltamivir treatment is recommended in any patients with influenza and pneumonia or severe illness, and critically ill patients, especially during the first 48 h of illness.

The treatment of patients with risk factors is recommended, considering their underlying : Alfredo Tagarro, Marta Cruz-Cañete, Enrique Otheo, Cristian Launes, José Antonio Couceiro, Carlos Pé.

In addition, to assess the cost-effectiveness of treating suspected influenza with oseltamivir in a primary care setting where standard treatment is no active medical intervention. Searching MEDLINE, EMBASE, HealthSTAR, Pascal, SciSearch and TOXLINE were searched from to Zanamivir is the treatment of choice for all patients where oseltamivir resistance has been demonstrated or is highly suspected (see pediatric section; inhaled zanamivir is not approved for use in children aged less than 5 years).

Oseltamivir also reduces the duration of influenza by a median of 36 hours, with nausea and vomiting as the primary reported adverse effects. The World Health Organization recommends oseltamivir as first-line treatment for H1N1, with the use of zanamivir only.

Oseltamivir and zanamivir are chemically related antiviral medications known as neuraminidase inhibitors that have activity against both influenza A and B viruses. oAmantadine and rimantadine are antiviral drugs in a class of medications known as adamantanes.

These medications are active against influenza A viruses, but not influenza B viruses. The WHO strongly recommends oseltamivir for the treatment of confirmed or suspected cases of human H5 infection and prophylaxis of those at high risk of infection.

In addition to oral dosing, nasogastric administration appears to be a viable option for the management of severely ill patients, as is the use of higher doses and prolonged schedules. Muthuri, S et al. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the influenza A (H1N1) pandemic: a systematic review and meta-analysis in hospitalized patients.

J Infect Dis(4) NICE Guideline: Amantadine, oseltamivir and zanamivir for the treatment of influenza. Based on CDC interim guidance on the use of antiviral medications for treatment of human infections with novel influenza A viruses associated with severe human disease, oseltamivir is recommended for treatment of influenza in hospitalized patients and outpatients with severe, complicated, or progressive illness due to avian influenza A virus (H7N9 or H5N1).

Oseltamivir as a prodrug is sold in capsules containing 30 mg, 45 mg or 75 mg oseltamivir phosphate and also as powder for oral suspension in water (6 mg/mL). For treatment of influenza, the recommended dose for adults is 75 mg, twice a day, for 5 days. Recommended treatment duration for uncomplicated influenza with a novel influenza A virus associated with severe human disease is two doses per day of oral oseltamivir or inhaled zanamivir for 5 days.

For IV peramivir, there are insufficient data for use in outpatients with infection with novel influenza A viruses that cause severe disease. Get this from a library. Oseltamivir for the treatment of suspected influenza: a clinical and economic assessment. [Donald Robert Husereau; Bruce Brady; Allison McGeer; Canadian Coordinating Office for Health Technology Assessment.].

Pregnant women with suspected or confirmed influenza infection should receive antiviral treatment with oseltamivir or zanamivir based on the current resistance patterns. Treatment within 48 hours of the onset of symptoms is ideal but treatment should not be withheld if the ideal window is missed.

Four antiviral drugs have been approved for the treatment of influenza: the NA inhibitors oseltamivir (Tamiflu), zanamivir (Relenza), and peramivir (Rapivab), and the.

Oseltamivirand zanamivirare also licensed for use in exceptional circumstances (e.g. when vaccination does not cover the infecting strain) to prevent influenza in an epidemic. There is evidence that some strains of influenza A virus have reduced susceptibility to. Oseltamivir is recommended for treatment for all ages and is the preferred agent to treat patients with severe or complicated influenza illness who are able to tolerate oral medications.

Zanamivir is approved and recommended to treat those aged ≥7 years and for prophylaxis in those aged ≥5 years. 1For treatment of suspected or confirmed oseltamivir resistant influenza, see section 2 For treatment of complicated influenza, see section Use second line treatment if there is poor.

Influenza Treatment: Mild renal dysfunction (CrCl greater than 60 to 90 mL/min): 75 mg orally twice a day For signs of abnormal behavior in oseltamivir-treated patients with influenza -Stop this drug and seek immediate medical attention if allergic-like reaction occurs/is suspected.Pregnant women with suspected or confirmed influenza infection should receive antiviral treatment with oseltamivir or zanamivir based on the current resistance patterns.

Treatment within 48 hours of the onset of symptoms is ideal but treatment should not be withheld if the ideal window is missed. Because of the high potential for morbidity and.Oseltamivir is the only influenza antiviral medication licensed for the treatment of influenza in infants at least 2 weeks of age, and specific dosing guidelines are available for this age group.Separate dosing is necessary for preterm infants because immature renal function may result in slower and variable drug clearance.